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Catalytic Enantioselective Intermolecular Desymmetrization of 3‐Substituted Oxetanes
Author(s) -
Wang Zhaobin,
Chen Zhilong,
Sun Jianwei
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300188
Subject(s) - desymmetrization , enantioselective synthesis , catalysis , functional group , intermolecular force , chemistry , compatibility (geochemistry) , combinatorial chemistry , reaction conditions , brønsted–lowry acid–base theory , organic chemistry , materials science , molecule , composite material , polymer
Wring it out : The title reaction proceeds in the presence of chiral Brønsted acid catalysts. This efficient ring‐opening process features low catalyst loading, mild reaction conditions, broad functional group compatibility, high enantioselectivity, and the capability to generate chiral quaternary centers. The highly functionalized desymmetrization products are versatile chiral building blocks in organic synthesis.