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NIR‐Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene‐Modified Mesoporous Silica
Author(s) -
Liu Jianan,
Bu Wenbo,
Pan Limin,
Shi Jianlin
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300183
Subject(s) - azobenzene , photoisomerization , mesoporous silica , nanoparticle , drug delivery , materials science , nanotechnology , molecule , mesoporous material , chemistry , organic chemistry , catalysis , isomerization
Photomediated drug release : Silica‐coated upconverting nanoparticles with mesopores modified by azobenzene molecules were synthesized. The azobenzene molecules make possible the release of the anticancer drug doxorubicin from the pore network of the mesoporous silica outer layer by irradiation with near‐infrared (NIR) laser light. The release is regulated by the trans – cis photoisomerization of the azobenzene molecules (see picture).