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Rhodium‐Catalyzed Asymmetric Arylative Cyclization of meso ‐1,6‐Dienynes Leading to Enantioenriched cis ‐Hydrobenzofurans
Author(s) -
He ZhiTao,
Tian Bing,
Fukui Yuki,
Tong Xiaofeng,
Tian Ping,
Lin GuoQiang
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300137
Subject(s) - desymmetrization , enantioselective synthesis , intramolecular force , chemistry , stereochemistry , bifunctional , organocatalysis , catalysis , combinatorial chemistry , organic chemistry
In tandem : The title reaction of cyclohexadienone‐containing meso ‐1,6‐dienynes with arylboronic acids through a tandem arylrhodation/conjugate addition sequence has been realized, and provides a novel approach to the enantioenriched cis ‐hydrobenzofurans with both excellent yields and enantioselectivities. binap=2,2′‐bis(diphenylphosphanyl)‐1,1′‐binaphthyl, Boc= tert ‐butoxycarbonyl.