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Redox‐Neutral Copper(II) Carboxylate Catalyzed α‐Alkynylation of Amines
Author(s) -
Das Deepankar,
Sun Aaron X.,
Seidel Daniel
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300021
Subject(s) - iminium , isomerization , redox , alkynylation , copper , catalysis , chemistry , computer science , carboxylate , combinatorial chemistry , database , organic chemistry
Cocktail of three : A new strategy for iminium ion isomerization was applied to the direct, redox‐neutral α‐alkynylation of amines. Copper(II) 2‐ethylhexanoate [Cu(2‐EH) 2 ] was identified as the optimal catalyst for this three‐component coupling reaction of secondary amines, aldehydes, and alkynes. MW=microwave.
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