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Multiphase Intrafibrillar Mineralization of Collagen
Author(s) -
Niu Lina,
Jiao Kai,
Ryou Heonjune,
Yiu Cynthia K. Y.,
Chen Jihua,
Breschi Lorenzo,
Arola Dwayne D.,
Pashley David H.,
Tay Franklin R.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201210259
Subject(s) - biomineralization , silicic acid , apatite , amorphous calcium phosphate , mineralization (soil science) , amorphous solid , crystallite , chemical engineering , collagen fibril , chemistry , phosphate , composite number , precipitation , materials science , mineralogy , biophysics , crystallography , composite material , biochemistry , biology , organic chemistry , physics , meteorology , nitrogen , engineering
Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.