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Studying 18 MDa Virus Assemblies with Native Mass Spectrometry
Author(s) -
Snijder Joost,
Rose Rebecca J.,
Veesler David,
Johnson John E.,
Heck Albert J. R.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201210197
Subject(s) - capsid , instrumentation (computer programming) , mass spectrometry , computer science , bacteriophage , service (business) , information retrieval , chemistry , computational biology , world wide web , virus , virology , biology , business , chromatography , biochemistry , programming language , escherichia coli , marketing , gene
Setting records : Native mass spectometry was used to study the assembly of the 18 MDa capsid of bacteriophage HK97. The previous record for the analysis of capsids by this method was around 10 MDa. The results indicate that the efficiency of desolvation is the main priority in improving native MS instrumentation.