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Formation of 1,3‐Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase
Author(s) -
Fuchs Sebastian W.,
Bozhüyük Kenan A. J.,
Kresovic Darko,
Grundmann Florian,
Dill Veronica,
Brachmann Alexander O.,
Waterfield Nicholas R.,
Bode Helge B.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201210116
Subject(s) - world wide web , class (philosophy) , natural (archaeology) , computer science , chemistry , biology , artificial intelligence , paleontology
Overlooked, but widespread! A new class of ketosynthases (DarB) involved in the biosynthesis of 1,3‐cyclohexanediones and dialkylresorcinols has been identified and characterized in detail. The presence of homologues in 89 different bacteria, including several pathogens, reveals that DarB as well as the corresponding natural products might be widespread, thus presenting a new but so far overlooked pathway to natural products.