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Isolation, Structure Elucidation, and Biological Activity of Maltepolides: Remarkable Macrolides from Myxobacteria
Author(s) -
Irschik Herbert,
Washausen Peter,
Sasse Florenz,
Fohrer Jörg,
Huch Volker,
Müller Rolf,
Prusov Evgeny V.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201210113
Subject(s) - myxobacteria , polyketide , stereochemistry , isolation (microbiology) , biology , chemistry , computational biology , bacteria , genetics , microbiology and biotechnology , biosynthesis , gene
Epoxide “swing” : A family of polyketide macrolactones originating from maltepolide E was discovered in Sorangium cellulosum So ce1485. Their structure was established by NMR experiments, molecular modeling, and X‐ray crystallography. Maltepolides induce rather rare morphological changes in the dividing transformed cell lines (see picture in the background).