Premium
Asymmetric Carbon–Carbon Bond Formation under Continuous‐Flow Conditions with Chiral Heterogeneous Catalysts
Author(s) -
Tsubogo Tetsu,
Ishiwata Takanori,
Kobayashi Shū
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201210066
Subject(s) - catalysis , carbon fibers , asymmetric carbon , continuous flow , enantioselective synthesis , chemistry , flow (mathematics) , materials science , combinatorial chemistry , chemical engineering , organic chemistry , optically active , biochemical engineering , composite material , mathematics , geometry , composite number , engineering
Catalytic asymmetric carbon–carbon bond‐forming reactions provide one of the most efficient ways to synthesize optically active compounds, and, accordingly, many chiral catalysts for these reactions have been developed in the past two decades. However, the efficiency of the catalysts in terms of turnover number (TON) is often lower than that of some other reactions, such as asymmetric hydrogenation, and this has been one of the obstacles for industrial applications. Although there are some difficulties in increasing the efficiency, the issues might be solved by using continuous flow in the presence of chiral heterogeneous catalysts. Indeed, continuous‐flow systems have several advantages over conventional batch systems. Here we summarize the recent progress in asymmetric CC bond‐forming reactions under continuous‐flow conditions with chiral heterogeneous catalysts.