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Supramolecular Self‐Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF‐α siRNA against Systemic Inflammation
Author(s) -
Yin Lichen,
Song Ziyuan,
Qu Qiuhao,
Kim Kyung Hoon,
Zheng Nan,
Yao Catherine,
Chaudhury Isthier,
Tang Haoyu,
Gabrielson Nathan P.,
Uckun Fatih M.,
Cheng Jianjun
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209991
Subject(s) - tumor necrosis factor alpha , lipopolysaccharide , gene silencing , systemic administration , inflammation , chemistry , supramolecular chemistry , small interfering rna , pharmacology , medicine , immunology , in vivo , biology , biochemistry , transfection , molecule , microbiology and biotechnology , organic chemistry , gene
A functional package : Multifunctional supramolecular self‐assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF‐α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF‐α production at an siRNA dose as low as 50 μg kg −1 , and thus protects mice from lipopolysaccharide‐induced hepatic injury.