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Copper‐Catalyzed Oxidative Cross‐Coupling of Sulfoximines and Alkynes
Author(s) -
Wang Long,
Huang He,
Priebbenow Daniel L.,
Pan FangFang,
Bolm Carsten
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209975
Subject(s) - catalysis , combinatorial chemistry , chemistry , coupling (piping) , oxidative phosphorylation , hydrolysis , computer science , service (business) , organic chemistry , materials science , business , biochemistry , metallurgy , marketing
A 'Cu'te couple : A synthetically useful protocol for the preparation of N‐alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper‐catalyzed oxidative cross‐coupling of NH‐sulfoximines and terminal alkynes (see scheme). The corresponding N‐acyl sulfoximines were also obtained selectively after acid‐catalyzed hydrolysis of the yne sulfoximines.

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