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Pyrene‐Tagged Dendritic Catalysts Noncovalently Grafted onto Magnetic Co/C Nanoparticles: An Efficient and Recyclable System for Drug Synthesis
Author(s) -
Keller Michel,
Collière Vincent,
Reiser Oliver,
Caminade AnneMarie,
Majoral JeanPierre,
Ouali Armelle
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209969
Subject(s) - drug delivery , nanoparticle , palladium , chemistry , ligand (biochemistry) , catalysis , pyrene , computer science , combinatorial chemistry , leaching (pedology) , nanotechnology , organic chemistry , materials science , environmental science , biochemistry , receptor , soil science , soil water
Hold on to your palladium! Phosphines have been grafted on magnetic Co/C nanoparticles through π–π interactions. The resulting Pd complexes showed high activity for Suzuki couplings and the system involving a dendritic ligand was recyclable, allowing the preparation of the drug Felbinac over 12 consecutive runs with minimal Pd leaching. After extraction with CH 2 Cl 2 , Felbinac met the requirements of the pharmaceutical industry (<5 ppm Pd).