One‐Pot Deracemization of  sec ‐Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases | Zendy

Schober Markus | Zendy; Toesch Michael | Zendy; Knaus Tanja | Zendy; Strohmeier Gernot A. | Zendy; van Loo Bert | Zendy; Fuchs Michael | Zendy; Hollfelder Florian | Zendy; Macheroux Peter | Zendy; Faber Kurt | Zendy

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One‐Pot Deracemization of sec ‐Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases

Author(s) -

Schober Markus,

Toesch Michael,

Knaus Tanja,

Strohmeier Gernot A.,

van Loo Bert,

Fuchs Michael,

Hollfelder Florian,

Macheroux Peter,

Faber Kurt

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201209946

Subject(s) - chemistry , hydrolysis , enantiomer , substrate (aquarium) , arylsulfatase , biotransformation , alkyl , biocatalysis , transformation (genetics) , enzyme , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , biochemistry , reaction mechanism , oceanography , gene , geology

Hand in hand : The title transformation was achieved using a pair of sulfatases acting through inversion and retention of configuration on opposite substrate enantiomers. Using Pseudomonas aeruginosa arylsulfatase PAS with alkylsulfatase PISA1 in one‐pot leads to sec ‐alcohols (80 to >99 % conversion) with 91 to greater than 99 % ee.

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