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Nucleoside‐Based Diarylethene Photoswitches and Their Facile Incorporation into Photoswitchable DNA
Author(s) -
Cahová Hana,
Jäschke Andres
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209943
Subject(s) - photochromism , diarylethene , pyrimidine , photoswitch , computer science , chemistry , combinatorial chemistry , covalent bond , azobenzene , photochemistry , stereochemistry , molecule , organic chemistry
Come into the light : Pyrimidine nucleosides were found to undergo fast and reversible ring closure upon irradiation with light when covalently attached to 2‐[2‐methyl‐5‐phenylthien‐3‐yl]cyclopent‐1‐ene (see scheme). Synthesis using an aqueous‐phase Suzuki–Miyaura cross‐coupling allows for one‐step conversion of iodo‐modified oligonucleotides into fully reversible DNA photoswitches.