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Enantioselective Palladium‐Catalyzed Decarboxylative Allylation of Carbazolones: Total Synthesis of (−)‐Aspidospermidine and (+)‐Kopsihainanine A
Author(s) -
Li Zeqian,
Zhang Shaoxiong,
Wu Shoutao,
Shen Xiaolei,
Zou Liwei,
Wang Fengqun,
Li Xiang,
Peng Fangzhi,
Zhang Hongbin,
Shao Zhihui
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209878
Subject(s) - enantioselective synthesis , tsuji–trost reaction , catalysis , palladium , total synthesis , chemistry , ligand (biochemistry) , alkylation , chiral ligand , organic chemistry , combinatorial chemistry , biochemistry , receptor
Functionalized chiral carbazolones with α‐quaternary carbon centers are formed through the ligand‐controlled Pd‐catalyzed enantioselective decarboxylative allylic alkylation of carbazolones (see scheme). This catalytic asymmetric reaction was employed as the key step in the total synthesis of aspidospermidine and (+)‐kopsihainanine A.