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Catalytic Generation and Selective Heterocoupling of Two Electron‐Rich Alkenes
Author(s) -
Galván Alicia,
Calleja Jonás,
Fañanás Francisco J.,
Rodríguez Félix
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209870
Subject(s) - cycloisomerization , stereocenter , combinatorial chemistry , chemistry , simple (philosophy) , computer science , cascade , catalysis , organic chemistry , enantioselective synthesis , philosophy , chromatography , epistemology
Complex heterocyclic products were synthesized from simple alkynamine and alkynol derivatives in a double cycloisomerization/heterodimerization cascade reaction (see scheme). The reaction includes the heterocoupling reaction of two different electron‐rich alkenes and leads to the formation of four new bonds and three stereocenters (two of them quaternary).