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Total Synthesis of Linoxepin through a Palladium‐Catalyzed Domino Reaction
Author(s) -
Tietze Lutz F.,
Duefert SveniaC.,
Clerc Jérôme,
Bischoff Matthias,
Maaß Christian,
Stalke Dietmar
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209868
Subject(s) - sonogashira coupling , domino , palladium , computer science , moiety , total synthesis , chemistry , catalysis , combinatorial chemistry , organic chemistry
Convergent and elegant : Linoxepin (see picture), a new lignan with an unusual oxepin moiety, has been synthesized in only 10 steps. The protecting‐group‐free total synthesis includes a palladium‐ catalyzed Sonogashira reaction and a domino carbopalladation/Heck reaction of an allylsilane.
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