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Controlling Helix Formation in the γ‐Peptide Superfamily: Heterogeneous Foldamers with Urea/Amide and Urea/Carbamate Backbones
Author(s) -
Pendem Nagendar,
Nelli Yella Reddy,
Douat Céline,
Fischer Lucile,
Laguerre Michel,
Ennifar Eric,
Kauffmann Brice,
Guichard Gilles
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209838
Subject(s) - urea , chemistry , amide , carbamate , peptide , helix (gastropod) , stereochemistry , hydrogen bond , combinatorial chemistry , biochemistry , molecule , organic chemistry , biology , ecology , snail
One fold to rule them all : New heterogeneous aliphatic backbone foldamers belonging to the γ‐peptide superfamily and containing various combinations of urea/amide (U/A) and urea/carbamate (U/C) units are reported. Structural studies at atomic resolution reveal hydrogen‐bonded helical structures akin to that formed by cognate U n homooligomers.