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Gold(III) Complexes Containing N‐Heterocyclic Carbene Ligands: Thiol “Switch‐on” Fluorescent Probes and Anti‐Cancer Agents
Author(s) -
Zou Taotao,
Lum Ching Tung,
Chui Stephen SinYin,
Che ChiMing
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209787
Subject(s) - carbene , chemistry , thiol , fluorescence , glutathione , ligand (biochemistry) , combinatorial chemistry , intracellular , cancer cell , photochemistry , biochemistry , cancer , receptor , catalysis , enzyme , biology , physics , quantum mechanics , genetics
Illuminating results : Activation of non‐emissive [Au III (N N N)(NHC)] + complexes (such as 1 ) through reduction by intracellular glutathione gives active Au I –NHC complexes, which show promising anti‐cancer properties, accompanied by release of the highly fluorescent ligand. The high fluorescence “switch‐on” efficiency makes these Au III complexes excellent probes for cellular thiol detection.