Palladium‐Catalyzed Asymmetric Allylic Alkylation of 3‐Aryloxindoles with Allylidene Dipivalate: A Useful Enol Pivalate Product | Zendy

Trost Barry M. | Zendy; Masters James T. | Zendy; Burns Aaron C. | Zendy

Premium

Palladium‐Catalyzed Asymmetric Allylic Alkylation of 3‐Aryloxindoles with Allylidene Dipivalate: A Useful Enol Pivalate Product

Author(s) -

Trost Barry M.,

Masters James T.,

Burns Aaron C.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201209783

Subject(s) - enol , tsuji–trost reaction , nucleophile , catalysis , palladium , alkylation , yield (engineering) , allylic rearrangement , chemistry , organic chemistry , materials science , metallurgy

Triple A : The catalytic asymmetric allylic alkylation (AAA) of 3‐aryloxindoles with allylidene dipivalate is described. This reaction affords stable, synthetically useful enol pivalates in high yield and with excellent regio‐ and enantioselectivity. A broad range of substrates is tolerated, including unprotected and 3‐heteroaryl nucleophiles.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research