Use of a Metallopeptide‐Based Mimic Provides Evidence for a Proton‐Coupled Electron‐Transfer Mechanism for Superoxide Reduction by Nickel‐Containing Superoxide Dismutase | Zendy

Shearer Jason | Zendy

Premium

Use of a Metallopeptide‐Based Mimic Provides Evidence for a Proton‐Coupled Electron‐Transfer Mechanism for Superoxide Reduction by Nickel‐Containing Superoxide Dismutase

Author(s) -

Shearer Jason

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201209746

Subject(s) - superoxide , chemistry , electron transfer , mechanism (biology) , superoxide dismutase , oxygen reduction , moiety , nickel , photochemistry , enzyme , stereochemistry , biochemistry , electrochemistry , philosophy , epistemology , organic chemistry , electrode

Sneaky little SOD! A metallopeptide‐based mimic of nickel‐containing superoxide dismutase was used to probe the mechanism of superoxide reduction by the metalloenzyme. Kinetic studies suggest a proton‐coupled electron‐transfer mechanism; large H/D kinetic isotope effects (KIE) are observed. XAS studies suggest the transferred H‐atom is in the form of a Ni II ‐S(H)‐Cys moiety (see graph).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research