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Interaction of Cationic Manganese Porphyrin with G‐Quadruplex Nucleic Acids Probed by Differential Labeling of the Two Faces of the Porphyrin
Author(s) -
Pradines Vincent,
Pratviel Geneviève
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209705
Subject(s) - porphyrin , chemistry , nucleic acid , g quadruplex , combinatorial chemistry , cationic polymerization , manganese , dna , atom (system on chip) , photochemistry , computer science , polymer chemistry , biochemistry , organic chemistry , embedded system
On the flip side : A free manganese porphyrin, when activated into a high‐valent metal‐oxo species, mediates O atom transfer (epoxidation) from both faces. This results in a mixed labeling of epoxide in labeled water. When the porphyrin (blue oval, see scheme) is bound to G‐quadruplex DNA (yellow boxes), the O atom transfer reaction takes place only on the accessible face of the porphyrin. This shows the binding mode of the porphyrin to the G‐quadruplex DNA.