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Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4‐Ethylphenylcobalamin, a Potential “Antivitamin B 12 ”
Author(s) -
Ruetz Markus,
Gherasim Carmen,
Gruber Karl,
Fedosov Sergey,
Banerjee Ruma,
Kräutler Bernhard
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209651
Subject(s) - vitamin b12 , chemistry , service (business) , computer science , business , biochemistry , marketing
Locked B 12 : 4‐Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B 12 antimetabolite features a strong CoC bond, and represents a “locked” form of vitamin B 12 (see picture). It may be used in animal studies to induce functional vitamin B 12 deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B 12 deficiency.