Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4‐Ethylphenylcobalamin, a Potential “Antivitamin B 12 ” | Zendy

Ruetz Markus | Zendy; Gherasim Carmen | Zendy; Gruber Karl | Zendy; Fedosov Sergey | Zendy; Banerjee Ruma | Zendy; Kräutler Bernhard | Zendy

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Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4‐Ethylphenylcobalamin, a Potential “Antivitamin B 12 ”

Author(s) -

Ruetz Markus,

Gherasim Carmen,

Gruber Karl,

Fedosov Sergey,

Banerjee Ruma,

Kräutler Bernhard

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201209651

Subject(s) - vitamin b12 , chemistry , service (business) , computer science , business , biochemistry , marketing

Locked B 12 : 4‐Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B 12 antimetabolite features a strong CoC bond, and represents a “locked” form of vitamin B 12 (see picture). It may be used in animal studies to induce functional vitamin B 12 deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B 12 deficiency.

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