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Effective Synthesis of Chiral N ‐Fluoroaryl Aziridines through Enantioselective Aziridination of Alkenes with Fluoroaryl Azides
Author(s) -
Jin LiMei,
Xu Xue,
Lu Hongjian,
Cui Xin,
Wojtas Lukasz,
Zhang X. Peter
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209599
Subject(s) - enantioselective synthesis , limiting , catalysis , combinatorial chemistry , reagent , olefin fiber , chemistry , computer science , rhodium , organic chemistry , mechanical engineering , engineering
The Co II complex of a D 2 ‐symmetric chiral porphyrin ([Co( D 2 ‐Por*)], see scheme) is a highly effective catalyst for the enantioselective aziridination of alkenes with fluoroaryl azides. The reaction can be performed at RT with low catalyst loading, and the olefin is the limiting reagent. Furthermore, the reaction is tolerant toward different combinations of aromatic olefins and fluoroaryl azides.