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Direct Selective Oxidative Cross‐Coupling of Simple Alkanes with Heteroarenes
Author(s) -
Antonchick Andrey P.,
Burgmann Lars
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209584
Subject(s) - hypervalent molecule , transformation (genetics) , simple (philosophy) , coupling (piping) , chemistry , oxidative phosphorylation , combinatorial chemistry , coupling reaction , computer science , iodine , organic chemistry , engineering , catalysis , mechanical engineering , biochemistry , philosophy , epistemology , gene
A dream reaction : An efficient and practical method for the oxidative cross‐coupling of heteroaromatic compounds and simple alkanes has been developed. The desired products are smoothly and regioselectively formed under mild reaction conditions at ambient temperature in a hypervalent‐iodine‐mediated transformation. The method allows for preferential transformation of stronger C sp 3H bonds in the presence of weaker C sp 3H bonds under metal‐free conditions.