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Rational Design of a Gold Carbene Precursor Complex for a Catalytic Cyclopropanation Reaction
Author(s) -
Ringger David H.,
Chen Peter
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209569
Subject(s) - cyclopropanation , carbene , catalysis , chemistry , combinatorial chemistry , transition metal carbene complex , computer science , organic chemistry
Bridging gas‐ and solution‐phase chemistry: A gold(I) carbene precursor complex has been developed and investigated for catalytic cyclopropanation. Formation of the carbene intermediate was first probed by mass spectrometry, followed by cyclopropanation of p ‐methoxystyrene in solution. The imidazolylidene leaving group serves as a base generated in situ that is necessary in the putative catalytic cycle.
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