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Practical and General Palladium‐Catalyzed Synthesis of Ketones from Internal Olefins
Author(s) -
Morandi Bill,
Wickens Zachary K.,
Grubbs Robert H.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209541
Subject(s) - scope (computer science) , palladium , simple (philosophy) , computer science , catalysis , substrate (aquarium) , service (business) , scheme (mathematics) , chemistry , transformation (genetics) , combinatorial chemistry , organic chemistry , business , mathematics , programming language , biology , ecology , mathematical analysis , philosophy , epistemology , marketing , biochemistry , gene
Make it simple! A convenient and general palladium‐catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed‐oil derivatives and a bioactive natural product (see scheme) are described, as well as intriguing mechanistic features.