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Palladium‐ and Copper‐Catalyzed Stereocontrolled Direct CH Fluoroalkenylation of Heteroarenes using gem ‐Bromofluoroalkenes
Author(s) -
Schneider Cédric,
Masi Daniela,
CouveBonnaire Samuel,
Pannecoucke Xavier,
Hoarau Christophe
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209446
Subject(s) - palladium , copper , catalysis , chemistry , combinatorial chemistry , organic chemistry
A gem of a reaction : The palladium‐ and copper‐catalyzed base‐assisted direct CH fluoroalkenylation of heterocycles 1 with gem ‐bromofluoroalkenes ( E )‐ 2 is reported. This method offers step‐economical and stereocontrolled access to valuable trisubstituted heteroarylated monofluoroalkenes ( Z )‐ 3 .
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