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DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy
Author(s) -
Chen Tao,
Wu Cuichen Sam,
Jimenez Elizabeth,
Zhu Zhi,
Dajac Joshua G.,
You Mingxu,
Han Da,
Zhang Xiaobing,
Tan Weihong
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209440
Subject(s) - molecular beacon , nucleic acid , oligonucleotide , biology , genetic enhancement , dna , gene , gene expression , microbiology and biotechnology , molecular probe , computational biology , gene silencing , microrna , biochemistry
Lighting the way with DNA : Molecular beacon micelle flares (MBMFs), based on self‐assembly of diacyllipid–molecular‐beacon conjugates (L‐MBs; see figure), have been developed for combined mRNA detection and gene therapy. These MBMFs were shown to inhibit a model gene in vitro and decrease the viability of cancer cells in culture.