Premium
Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design
Author(s) -
JiménezMoreno Ester,
GómezPinto Irene,
Corzana Francisco,
Santana Andrés G.,
Revuelta Julia,
Bastida Agatha,
JiménezBarbero Jesus,
González Carlos,
Asensio Juan Luis
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209434
Subject(s) - reactivity (psychology) , rna , computer science , chemistry , drug , combinatorial chemistry , information retrieval , computational biology , service (business) , biochemistry , medicine , biology , pharmacology , alternative medicine , pathology , gene , economy , economics
When you're in a (RNA) bind : An NMR‐based method to explore the reactivity of ligand/RNA complexes can be used as source of valuable information for drug design. By combining NMR spectroscopy and a simple isotopic labeling strategy (see picture), positional chemical reactivity information can be readily extracted from complex aminoglycoside mixtures. C green, N blue, O red, Me purple.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom