Arylamine‐Catalyzed Enamine Formation: Cooperative Catalysis with Arylamines and Acids | Zendy

Deng Yongming | Zendy; Liu Lu | Zendy; Sarkisian Ryan G. | Zendy; Wheeler Kraig | Zendy; Wang Hong | Zendy; Xu Zhenghu | Zendy

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Arylamine‐Catalyzed Enamine Formation: Cooperative Catalysis with Arylamines and Acids

Author(s) -

Deng Yongming,

Liu Lu,

Sarkisian Ryan G.,

Wheeler Kraig,

Wang Hong,

Xu Zhenghu

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201209268

Subject(s) - enamine , enantioselective synthesis , lewis acids and bases , catalysis , chemistry , combinatorial chemistry , component (thermodynamics) , organic chemistry , computer science , physics , thermodynamics

Powerful combination : Arylamines and metal Lewis acids are used as catalysts in the highly chemo‐ and enantioselective three‐component inverse‐electron‐demand aza‐Diels–Alder reaction of cyclic ketones with enones. The enantioselectivity is introduced by a simple chiral anion (see scheme). Arylamines can also serve as effective enamine catalysts in combination with either a metal Lewis acid or a Brønsted acid.

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