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Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate
Author(s) -
Fier Patrick S.,
Hartwig John F.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209250
Subject(s) - simple (philosophy) , computer science , reagent , service (business) , chemistry , tandem , aryl , combinatorial chemistry , world wide web , organic chemistry , engineering , business , aerospace engineering , marketing , philosophy , alkyl , epistemology
The difluoromethylation of phenols with a simple, non‐ozone‐depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional‐group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers.