Premium
A Detailed View of 2‐Methylisoborneol Biosynthesis
Author(s) -
Brock Nelson L.,
Ravella Srinivasa R.,
Schulz Stefan,
Dickschat Jeroen S.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209173
Subject(s) - odor , biosynthesis , cationic polymerization , chemistry , biochemistry , organic chemistry , enzyme
Odor of earth : Several homomonoterpenes were identified in actinomycetes that produce 2‐methylisoborneol (2‐MIB, see scheme, which is responsible for an earthy odor in drinking water). Their occurrence clarifies the 2‐MIB pathway, because they are derived from cationic intermediates that are otherwise difficult to detect. A highly sensitive method using feeding experiments with 13 C‐labeled precursors gives detailed insights into 2‐MIB biosynthesis.