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Two‐Way Nanopore Sensing of Sequence‐Specific Oligonucleotides and Small‐Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures
Author(s) -
Liu Nannan,
Jiang Yanan,
Zhou Yahong,
Xia Fan,
Guo Wei,
Jiang Lei
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209162
Subject(s) - nanopore , oligonucleotide , nanopore sequencing , dna , sequence (biology) , computer science , nanotechnology , computational biology , dna sequencing , chemistry , materials science , biology , biochemistry
Pore me another one : Sub‐nanomolar sequence‐specific DNA detection and sub‐micromolar small‐molecule (ATP) detection was shown by way of self‐assembly and disassembly of DNA superstructures within solid‐state nanopores (see scheme). These DNA structures provide a built‐in amplification mechanism to increase the signal strength and sensitivity. This sensor was also shown to work within complex mixtures, such as mammalian serum.