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Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules
Author(s) -
Yoshikawa Yuko,
Umezawa Naoki,
Imamura Yuki,
Kanbe Toshio,
Kato Nobuki,
Yoshikawa Kenichi,
Imanaka Tadayuki,
Higuchi Tsunehiko
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209144
Subject(s) - polyamine , spermine , dna , molecule , stereochemistry , toroid , chemistry , compaction , combinatorial chemistry , biophysics , biochemistry , biology , materials science , physics , organic chemistry , enzyme , plasma , quantum mechanics , composite material
Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.