Iridium‐Catalyzed Asymmetric Hydrogenation of α‐Alkylidene Succinimides | Zendy

Liu Yuanyuan | Zendy; Zhang Wanbin | Zendy

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Iridium‐Catalyzed Asymmetric Hydrogenation of α‐Alkylidene Succinimides

Author(s) -

Liu Yuanyuan,

Zhang Wanbin

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201209126

Subject(s) - succinimides , succinimide , catalysis , iridium , trifluoromethyl , chemistry , boron , asymmetric hydrogenation , organic chemistry , imide , reaction conditions , medicinal chemistry , combinatorial chemistry , enantioselective synthesis , alkyl

Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3‐benzyl pyrrolidines and 1‐hydroxypyrrolidine‐2,5‐diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF − =tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate.

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