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Cross‐Metathesis/Iridium(I)‐catalyzed Allylic Etherification Strategy: (Iterative) Catalytic Asymmetric Synthesis of syn‐ and anti ‐1,2‐Diols
Author(s) -
Kim Dongeun,
Lee Jae Seung,
Kong Suk Bin,
Han Hyunsoo
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209112
Subject(s) - iridium , catalysis , computer science , metathesis , combinatorial chemistry , allylic rearrangement , control (management) , chemistry , organic chemistry , polymerization , polymer , artificial intelligence
Protection optional : The title reaction strategy is used to prepare 1,2‐diols with complete control of their absolute and relative stereochemistry. The method tolerates free and Me‐/Bn‐/TBS‐protected alcohol functionalities, and its diastereoselectivity is controlled by the stereochemistry of the ligands/catalysts used. Protected 1,2,3,4‐tetraols are synthesized by iterative applications of the strategy.