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Kinetic Resolution of Tertiary Alcohols: Highly Enantioselective Access to 3‐Hydroxy‐3‐Substituted Oxindoles
Author(s) -
Lu Shenci,
Poh Si Bei,
Siau WoonYew,
Zhao Yu
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201209043
Subject(s) - enantioselective synthesis , carbene , kinetic resolution , computer science , chemistry , combinatorial chemistry , catalysis , organic chemistry
Enantioselective : The first highly enantioselective kinetic resolution of 3‐hydroxy‐3‐substituted oxindoles has been developed through oxidative esterification catalyzed by a N‐heterocyclic carbene (see picture). This method uses a simple procedure and provides 3‐hydroxy‐oxindoles with various substituents at the 3‐position in excellent enantiopurity. S =selectivity.

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