Two‐Color Glycan Labeling of Live Cells by a Combination of Diels–Alder and Click Chemistry | Zendy

Niederwieser Andrea | Zendy; Späte AnneKatrin | Zendy; Nguyen Long Duc | Zendy; Jüngst Christian | Zendy; Reutter Werner | Zendy; Wittmann Valentin | Zendy

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Two‐Color Glycan Labeling of Live Cells by a Combination of Diels–Alder and Click Chemistry

Author(s) -

Niederwieser Andrea,

Späte AnneKatrin,

Nguyen Long Duc,

Jüngst Christian,

Reutter Werner,

Wittmann Valentin

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201208991

Subject(s) - click chemistry , cycloaddition , glycan , azide , chemistry , diels–alder reaction , alkyne , visualization , combinatorial chemistry , organic chemistry , computer science , biochemistry , catalysis , glycoprotein , artificial intelligence

One is not enough : Terminal alkenes are used as chemical reporters and ligation partners for 1,2,4,5‐tetrazines in a Diels–Alder reaction with inverse electron demand (DARinv). Combination with strain‐promoted azide–alkyne cycloaddition (SPAAC) allows the visualization of two different glycan structures in one experiment.

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