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A Mesoporous‐Silica‐Immobilized Oxovanadium Cocatalyst for the Lipase‐Catalyzed Dynamic Kinetic Resolution of Racemic Alcohols
Author(s) -
Egi Masahiro,
Sugiyama Koji,
Saneto Moriaki,
Hanada Ryosuke,
Kato Katsuya,
Akai Shuji
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208988
Subject(s) - kinetic resolution , catalysis , lipase , mesoporous silica , mesoporous material , chemistry , resolution (logic) , organic chemistry , optically active , enantioselective synthesis , combinatorial chemistry , enzyme , artificial intelligence , computer science
V for resolution : A new oxovanadium catalyst (V‐MPS; see scheme) immobilized in the pores of mesoporous silica has been developed. The combined use of V‐MPS and lipases achieved the dynamic kinetic resolution of a wide range of racemic alcohols ( 1 or 2 ) to produce optically active esters 3 in high chemical and optical yields. The paired catalysts retained high catalytic activity when reused up to six times.