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The Flavoprotein Dodecin as a Redox Probe for Electron Transfer through DNA
Author(s) -
Yu Yaming,
Heidel Björn,
Parapugna Tamara Lourdes,
WenderholdReeb Sabine,
Song Bo,
Schönherr Holger,
Grininger Martin,
Nöll Gilbert
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208987
Subject(s) - flavin group , electron transfer , chemistry , redox , dna , flavoprotein , photochemistry , monolayer , nucleobase , cyclic voltammetry , base pair , flavin adenine dinucleotide , electrochemistry , cofactor , electrode , inorganic chemistry , biochemistry , enzyme
Flavin away : Dodecin binds oxidized flavins, whereas reduction of the bound flavin induces dissociation of the holoprotein into apododecin and free flavins. The stepwise reconstitution of dodecin on flavin‐terminated ds‐DNA monolayers showed that although electrochemical flavin reduction (i.e. electron transfer through DNA) was not possible, apododecin (gray circles) could be released by chemical reduction (see scheme).