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Silver‐Catalyzed Hydrotrifluoromethylation of Unactivated Alkenes with CF 3 SiMe 3
Author(s) -
Wu Xinyue,
Chu Lingling,
Qing FengLing
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208971
Subject(s) - trifluoromethylation , chemistry , allylic rearrangement , catalysis , service (business) , combinatorial chemistry , computer science , organic chemistry , world wide web , business , alkyl , marketing , trifluoromethyl
A silver bullet : The title reaction results in selective formation of trifluoromethylated alkanes, and is in contrast to the previously reported transition‐metal‐catalyzed trifluoromethylation of olefins to generate a series of trifluoromethylated allylic compounds. Preliminary mechanistic investigations indicate that the current hydrotrifluoromethylation proceeds through a pathway involving a CF 3 radical species.