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Abyssomicins from the South China Sea Deep‐Sea Sediment Verrucosispora sp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs
Author(s) -
Wang Qian,
Song Fuhang,
Xiao Xue,
Huang Pei,
Li Li,
Monte Aaron,
AbdelMageed Wael M.,
Wang Jian,
Guo Hui,
He Wenni,
Xie Feng,
Dai Huanqin,
Liu Miaomiao,
Chen Caixia,
Xu Hao,
Liu Mei,
Piggott Andrew M.,
Liu Xueting,
Capon Robert J.,
Zhang Lixin
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208801
Subject(s) - tuberculosis , mycobacterium tuberculosis , thioether , antibiotics , microbiology and biotechnology , biology , chemistry , medicine , stereochemistry , pathology
From the deep : The title actinomycete yielded three new abyssomicins J–L. The dimeric thioether J (see scheme) represents a unique example of a masked Michael acceptor with anti‐TB properties. Mechanistic insights into the biosynthesis, biomimetic synthesis, stability, and biological mechanism of action of abyssomicins aid our understanding of, and prospects for the development of Michael‐acceptor‐based drugs.