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Fulvenes as Effective Dipolarophiles in Copper(I)‐Catalyzed [6+3] Cycloaddition of Azomethine Ylides: Asymmetric Construction of Piperidine Derivatives
Author(s) -
He ZhaoLin,
Teng HuaiLong,
Wang ChunJiang
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208799
Subject(s) - piperidine , fulvenes , cycloaddition , chemistry , catalysis , combinatorial chemistry , computer science , organic chemistry
As easy as π : Fulvenes serve as 6π dipolarophiles in the title reaction in the presence of the chiral Cu I /( S )‐ L complex. The present system provides a unique and straightforward access to enantioenriched, highly functionalized piperidine derivatives in good yields and excellent diastereoselectivities and enantioselectivities.