Synthesis of Aryl Ethers from Benzoates through Carboxylate‐Directed CH‐Activating Alkoxylation with Concomitant Protodecarboxylation | Zendy

Bhadra Sukalyan | Zendy; Dzik Wojciech I. | Zendy; Gooßen Lukas J. | Zendy

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Synthesis of Aryl Ethers from Benzoates through Carboxylate‐Directed CH‐Activating Alkoxylation with Concomitant Protodecarboxylation

Author(s) -

Bhadra Sukalyan,

Dzik Wojciech I.,

Gooßen Lukas J.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201208755

Subject(s) - carboxylate , bimetallic strip , benzoates , aryl , chemistry , organic chemistry , catalysis , copper , medicinal chemistry , alkyl

One in, one out : In the presence of a copper/silver bimetallic catalyst system, aromatic carboxylate salts undergo ortho CH alkoxylation with concomitant loss of the carboxylate directing group in a protodecarboxylation step (see scheme, FG=functional group). This process provides a convenient synthetic access to the important class of aromatic ethers from widely available carboxylic acids.

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