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A Plasmonic DNAzyme Strategy for Point‐of‐Care Genetic Detection of Infectious Pathogens
Author(s) -
Zagorovsky Kyryl,
Chan Warren C. W.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208715
Subject(s) - point of care , deoxyribozyme , computer science , computational biology , point of care testing , virology , biology , medicine , genetics , immunology , dna , nursing
Always use detection : Signal amplification from DNAzymes (see scheme) was combined with gold nanoparticles (GNPs) to give a simple and sensitive colorimetric assay for various genetic targets. The assay has 50 p M sensitivity without the need for purification steps and can detect multiple targets in parallel. This was applied to rapidly detect gonorrhea, syphilis, malaria, and hepatitis B infections.
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