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Asymmetric Total Synthesis of Leucosceptroid B
Author(s) -
Huang Xuan,
Song Liqiang,
Xu Jiao,
Zhu Guili,
Liu Bo
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208687
Subject(s) - total synthesis , natural product , epimer , flexibility (engineering) , chemistry , stereochemistry , combinatorial chemistry , mathematics , statistics
Less stable, but natural : The asymmetric total synthesis of leucosceptroid B (see scheme) has been accomplished in 19 steps. Thermodynamically, this natural product proved to be less stable than its C11 epimer, a synthetic intermediate. This synthesis features a high degree of flexibility, facilitating its application to the preparation of a broad range of other natural derivatives.