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Directional Selection Precedes Conformational Selection in Ubiquitin–UIM Binding
Author(s) -
Long Dong,
Brüschweiler Rafael
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208683
Subject(s) - ubiquitin , ubiquitin ligase , population , chemistry , selection (genetic algorithm) , biophysics , computational biology , biology , biochemistry , computer science , artificial intelligence , gene , demography , sociology
Meeting your match : The early molecular recognition event of ubiquitin with the ubiquitin‐interacting motif (UIM) of Hrs protein starts out with a directional bias in the position of UIM, increasingly favoring directions facing the binding interface of ubiquitin as the distance decreases (see figure). This process, which is driven by electrostatic long‐range interactions, precedes an internal conformational population shift.