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Cobalt‐Catalyzed C4‐Selective Direct Alkylation of Pyridines
Author(s) -
Andou Takashi,
Saga Yutaka,
Komai Hirotomo,
Matsunaga Shigeki,
Kanai Motomu
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208666
Subject(s) - alkylation , catalysis , cobalt , pyridine , chemistry , substrate (aquarium) , combinatorial chemistry , organic chemistry , oceanography , geology
How pyridine got its tail : A new catalyst for the atom‐economical C4‐selective direct alkylation of pyridines is described. A combination of CoBr 2 and LiBEt 3 H catalyzes the reaction of pyridines with 1‐alkenes at 70 °C to give alkylation products with C4/C2 ratios of >20:1. Substrate/catalyst ratios of up to 4000, and a turnover number of 3440 were achieved.