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Palladium/Chiral Amine Co‐catalyzed Enantioselective β‐Arylation of α,β‐Unsaturated Aldehydes
Author(s) -
Ibrahem Ismail,
Ma Guangning,
Afewerki Samson,
Córdova Armando
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208634
Subject(s) - enantioselective synthesis , palladium , amine gas treating , aryl , catalysis , chemistry , organic chemistry , conjugate , combinatorial chemistry , mathematics , mathematical analysis , alkyl
Palladium and a simple chiral amine are used as co‐catalysts for the enantioselective conjugate addition of aryl boronic acids to α,β‐unsaturated aldehydes (see scheme). The synthetic utility of this co‐catalyzed reaction was demonstrated in the short total syntheses of ( R )‐(−)‐curcumene and 4‐aryl‐2‐ones.